• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
CARDOTEL 5/40 MG is indicated for the treatment of essential hypertension, especially in patients whose blood pressure is not adequately controlled on monotherapy. It also reduces the risk of cardiovascular events.
Pharmacology:
Telmisartan is an angiotensin II receptor blocker (ARB) that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II.
Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle and myocardium, leading to vasodilation.
The combination provides additive antihypertensive effects by targeting different pathways.
Dosage & Administration:
One tablet daily, preferably at the same time each day, with or without food.
Dose adjustments should be based on clinical response and tolerance.
Not recommended as initial therapy unless clinically justified.
Interaction:
Increased risk of hyperkalemia with potassium supplements or potassium-sparing diuretics (due to Telmisartan).
Caution with other antihypertensives (additive effect).
NSAIDs may reduce the antihypertensive effect.
Grapefruit juice may affect Amlodipine metabolism.
Contraindications:
Hypersensitivity to Telmisartan, Amlodipine, or any component of the formulation
Severe hypotension or cardiogenic shock
Pregnancy (especially 2nd and 3rd trimesters)
Severe hepatic impairment
Side Effects:
Dizziness, peripheral edema, fatigue
Hypotension, flushing
Hyperkalemia (rare)
Rare: Angioedema, renal dysfunction
Pregnancy & Lactation:
Contraindicated during pregnancy—ARBs can cause fetal harm. Use with caution in lactating mothers as Amlodipine is excreted in breast milk.
Precautions & Warnings:
Monitor blood pressure, renal function, and electrolytes regularly
Use cautiously in patients with heart failure or liver/kidney impairment
Avoid abrupt withdrawal
Caution in patients with volume depletion or severe aortic stenosis
Therapeutic Class:
Telmisartan: Angiotensin II Receptor Blockers (ARBs)
Amlodipine: Calcium Channel Blockers (Dihydropyridine group)
Storage Conditions:
Store below 30°C in a dry place, away from sunlight. Keep out of reach of children.