Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
🔸 Indications:
Corangi 10 mg is indicated for:
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Chronic heart failure (NYHA Class II to IV) with reduced ejection fraction
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Stable angina pectoris in patients with normal sinus rhythm and contraindication to beta-blockers or in combination with them
🔸 Pharmacology:
Ivabradine selectively inhibits the funny current (If) in the sinoatrial node of the heart, leading to heart rate reduction without affecting myocardial contractility or ventricular repolarization, improving oxygen balance and heart efficiency.
🔸 Dosage:
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Initial dose: 5 mg twice daily
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May be increased to 7.5–10 mg/day depending on heart rate and clinical response
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Max dose: 7.5 mg twice daily (total 15 mg/day)
🔸 Administration:
Take orally with meals to enhance absorption. Maintain regular dosing time daily.
🔸 Interaction:
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Avoid use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
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Use cautiously with verapamil or diltiazem
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Interaction with QT-prolonging drugs
🔸 Contraindications:
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Severe bradycardia (<60 bpm)
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Acute decompensated heart failure
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Pacemaker dependence
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Severe hepatic impairment
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Pregnancy and lactation
🔸 Side Effects:
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Bradycardia (slow heart rate)
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Luminous phenomena (phosphenes)
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Headache
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Dizziness
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Atrial fibrillation (rare)
🔸 Pregnancy & Lactation:
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Contraindicated during pregnancy
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Not recommended during breastfeeding unless advised by a physician
🔸 Precautions & Warnings:
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Monitor heart rate regularly
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Caution in patients with low blood pressure or arrhythmia
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Not for use in children under 18 years
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May cause visual disturbances (transient brightness)
🔸 Therapeutic Class:
Heart rate-reducing agents / Selective If-channel inhibitors
🔸 Storage Conditions:
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Store below 25°C
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Protect from moisture and heat
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Keep out of reach of children
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