Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Gastroesophageal reflux disease (GERD)
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Duodenal and gastric ulcers
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Zollinger-Ellison syndrome
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Erosive esophagitis
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Maintenance therapy after healing of erosive esophagitis
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Helicobacter pylori eradication (with antibiotics)
Pharmacology:
Rabeprazole inhibits the H+/K+ ATPase enzyme in gastric parietal cells, reducing acid secretion and promoting healing of acid-related mucosal damage.
Dosage & Administration:
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Typical dose: 20 mg once daily before meals, usually in the morning
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Duration varies with condition: 4–8 weeks for GERD; 4–6 weeks for ulcers
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For H. pylori eradication: 20 mg twice daily with antibiotics for 7–10 days
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Swallow whole; do not crush or chew
Interaction:
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May affect absorption of drugs requiring acidic environment (ketoconazole, atazanavir)
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Can increase blood levels of digoxin, warfarin, cyclosporine
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Caution with methotrexate due to delayed clearance
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Antacids do not affect Rabeprazole efficacy
Contraindications:
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Known hypersensitivity to Rabeprazole or related compounds
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Severe hepatic impairment without medical supervision
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Use with rilpivirine-containing drugs
Side Effects:
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Headache, diarrhea, nausea, abdominal pain
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Constipation, flatulence
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Rare: Vitamin B12 deficiency, hypomagnesemia, fractures with long-term use
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Skin rash, liver enzyme elevation (rare)
Pregnancy & Lactation:
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Use only if clearly needed during pregnancy
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Excreted in breast milk; use caution when breastfeeding
Precautions & Warnings:
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Long-term use may increase gastric cancer risk
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Monitor magnesium levels during prolonged therapy
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Evaluate for H. pylori infection in recurrent ulcers
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Adjust dose in hepatic impairment
Therapeutic Class:
Proton Pump Inhibitors (PPIs)
Storage Conditions:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
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