Zofen TS 1.5 mg is a prescription medication containing Pizotifen, a serotonin and histamine antagonist. It is primarily used as a prophylactic treatment for vascular headaches, including classical migraine, common migraine, and cluster headaches. By inhibiting the actions of serotonin and histamine, Zofen TS helps prevent the onset of migraine attacks but is not effective in relieving migraines once they have started