• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Beklo is indicated for:
Relief of muscle spasticity due to multiple sclerosis
Muscle spasticity resulting from spinal cord injury or disease
Cerebral palsy, stroke, or other neurological disorders with spasticity
Pharmacology:
Baclofen is a centrally acting skeletal muscle relaxant. It is a gamma-aminobutyric acid (GABA) derivative that acts on GABA-B receptors in the spinal cord, reducing the release of excitatory neurotransmitters and inhibiting reflexes responsible for muscle spasticity. This results in muscle relaxation and relief from stiffness and spasms.
Dosage & Administration:
Initial dose: 5 mg orally three times daily
May be increased by 5 mg per dose every 3 days as needed
Maintenance dose: Usually 40–80 mg/day in divided doses
Take with food to reduce gastrointestinal discomfort
Do not stop abruptly — taper gradually to prevent withdrawal symptoms
Interaction:
Enhanced CNS depression with alcohol, benzodiazepines, opioids, antihistamines
May enhance the effects of other muscle relaxants
Caution with tricyclic antidepressants (may potentiate muscle weakness)
Contraindications:
Hypersensitivity to Baclofen
Active peptic ulcer (relative)
Use cautiously in patients with epilepsy or renal impairment
Side Effects:
Common: Drowsiness, dizziness, weakness, nausea, fatigue
Less common: Headache, hypotension, confusion, constipation
Rare: Seizures, hallucinations (particularly with abrupt withdrawal), respiratory depression
Pregnancy & Lactation:
Use in pregnancy only if clearly needed; safety not established. Baclofen is excreted in breast milk; use with caution during lactation under physician supervision.
Precautions & Warnings:
Avoid activities requiring mental alertness (e.g., driving) until drug effects are known
Use cautiously in elderly and renal-impaired patients
Do not discontinue suddenly to avoid hallucinations, seizures, or rebound spasticity
Monitor renal function in long-term use
Therapeutic Class:
Centrally acting muscle relaxants
Storage Conditions:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.