Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Ropitor is indicated for:
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Hyperlipidemia and mixed dyslipidemia
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Primary and secondary prevention of cardiovascular events
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Homozygous familial hypercholesterolemia (HoFH)
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Slowing progression of atherosclerosis
Pharmacology:
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. It increases the number of LDL receptors on hepatocyte surfaces, enhancing LDL uptake and breakdown, and inhibits hepatic synthesis of VLDL, lowering overall LDL and triglyceride levels while increasing HDL.
Dosage & Administration:
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Usual starting dose: 5–10 mg once daily
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Can be taken with or without food, preferably at the same time every day
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Dose adjusted based on lipid goals and patient tolerance
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Regular lipid profile monitoring recommended
Interaction:
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Increased risk of myopathy with cyclosporine, gemfibrozil, or other fibrates
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Use with caution with antacids (take Ropitor 2 hours before or 4 hours after antacids)
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May increase INR in patients taking warfarin
Contraindications:
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Hypersensitivity to Rosuvastatin or any component
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Active liver disease or unexplained persistent elevations in hepatic transaminases
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Pregnancy and lactation (contraindicated)
Side Effects:
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Common: Headache, muscle pain, abdominal pain, nausea
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Less common: Liver enzyme elevation, weakness
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Serious (rare): Rhabdomyolysis, myopathy, kidney dysfunction
Pregnancy & Lactation:
Contraindicated in pregnancy and breastfeeding due to potential harm to fetus or infant. Use effective contraception during therapy.
Precautions & Warnings:
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Monitor liver enzymes before and during treatment
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Discontinue if symptoms of myopathy or rhabdomyolysis occur
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Use lower doses in Asian patients or those with renal impairment
Therapeutic Class:
Lipid-lowering agents (Statins)
Storage Conditions:
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
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