Nebilol Plus 5 mg + 12.5 mg is a combination medication manufactured by Opsonin Pharma Limited in Bangladesh. It combines Nebivolol (5 mg), a beta-blocker, with Hydrochlorothiazide (12.5 mg), a thiazide diuretic. This combination is primarily used to treat essential hypertension (high blood pressure) by reducing both heart rate and fluid volume, thereby lowering blood pressure and reducing the risk of heart-related complications.