Sitamet is an oral combination medication used to manage type 2 diabetes mellitus. It combines two active ingredients: Sitagliptin and Metformin Hydrochloride. Sitagliptin, a DPP-4 inhibitor, works by increasing insulin release and decreasing glucagon secretion in response to meals, helping to improve blood sugar control. Metformin, a biguanide, works by reducing the amount of glucose produced by the liver and improving insulin sensitivity in peripheral tissues, which aids in better glucose utilization. This combination therapy is typically used when diet and exercise alone do not provide adequate control of blood sugar levels in adults with type 2 diabetes. Sitamet should be taken with meals to reduce the gastrointestinal side effects commonly associated with Metformin, and the dosage is usually adjusted according to the patient's response to the medication. It is important to monitor renal function during treatment and consult a healthcare provider to ensure the medication is appropriate for individual health needs.