Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications
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Type 2 Diabetes Mellitus
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When diet, exercise, and single-agent therapy fail to achieve adequate glycemic control
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Replacement of combination therapy of Glimepiride and Metformin
Pharmacology
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Glimepiride (2 mg): A sulfonylurea antidiabetic agent that decreases blood glucose concentration by stimulating insulin release from pancreatic beta cells and increasing peripheral tissue sensitivity to insulin.
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Metformin (500 mg): A biguanide that decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage
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Adults: As directed by the physician, typically taken once daily with the first meal of the day.
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Geriatric: Dose adjustment may be necessary based on renal function.
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Children: Not recommended for use in children below 18 years.
Administration
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Take the tablet orally with a glass of water.
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Swallow the tablet whole; do not chew, crush, or break it.
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Preferably take with food to minimize gastrointestinal side effects.
Interaction
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May interact with other antidiabetic agents, increasing the risk of hypoglycemia.
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Alcohol may potentiate the blood-glucose-lowering effect, increasing the risk of lactic acidosis.
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Certain medications like beta-blockers, clonidine, and reserpine may mask symptoms of hypoglycemia.
Contraindications
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Hypersensitivity to Glimepiride, Metformin, or any component of the tablet.
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Type 1 Diabetes Mellitus.
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
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Severe renal or hepatic impairment.
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History of lactic acidosis.
Side Effects
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Common: Hypoglycemia, nausea, vomiting, headache, dizziness, stomach ache.
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Less common: Indigestion, bitter taste, yellow discoloration of skin or eyes.
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Serious: Lactic acidosis (rare), especially in patients with renal or hepatic dysfunction.
Pregnancy & Lactation
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Pregnancy: Category C. Use only if the potential benefit justifies the potential risk to the fetus.
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Lactation: Not recommended; Metformin is excreted in breast milk, and its effect on the nursing infant is unknown.
Precautions & Warnings
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Monitor renal and hepatic function regularly.
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Adjust dosage in elderly patients or those with renal impairment.
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Inform the healthcare provider of any history of cardiovascular disease.
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Avoid alcohol consumption during treatment.
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Educate patients on recognizing signs of hypoglycemia and appropriate management.
Therapeutic Class
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Antidiabetic Combination
Storage Conditions
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Store at room temperature (20–25°C) in a dry place, away from light.
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Keep out of reach of children.
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