axipraz 375 mg + 20 mg is a combination tablet containing two active ingredients: Naproxen Sodium (375 mg) and Esomeprazole Magnesium (20 mg). Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by inhibiting the production of prostaglandins. Esomeprazole is a proton pump inhibitor (PPI) that decreases stomach acid production, thereby protecting the stomach lining from potential damage caused by NSAIDs.