Olmezest 40 mg is a prescription medication containing olmesartan medoxomil, an angiotensin II receptor blocker (ARB) used primarily to treat high blood pressure (hypertension). By blocking the effects of angiotensin II, a hormone that constricts blood vessels, Olmezest helps relax and widen blood vessels, thereby lowering blood pressure and reducing the risk of strokes, heart attacks, and kidney problems. The typical starting dose is 20 mg once daily, which may be increased to 40 mg if blood pressure is not adequately controlled. Olmezest is usually taken once daily, with or without food, and should be swallowed whole. Common side effects may include dizziness, headache, nausea, diarrhea, and fatigue. Patients should avoid using Olmezest during pregnancy, especially in the second and third trimesters, as it may harm the unborn baby. Regular monitoring of kidney function and electrolytes is recommended during treatment.