Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Mirtaz is indicated for:
-
Major depressive disorder (MDD)
-
Anxiety associated with depression
-
Sleep disturbances and insomnia related to depressive illness
-
Often used off-label at low doses for sleep support in patients with anxiety or depression
Pharmacology:
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). It enhances central noradrenergic and serotonergic activity by blocking presynaptic α2-adrenergic receptors. It also blocks 5-HT2 and 5-HT3 receptors, which contributes to its anxiolytic and sleep-promoting properties.
Dosage & Administration:
-
Initial dose: 7.5–15 mg once daily, usually taken at bedtime
-
Maintenance dose: Can be increased gradually to 30–45 mg daily as needed
-
Should be taken regularly at the same time each day
-
Swallow whole with water, with or without food
Interaction:
-
Increased risk of serotonin syndrome when used with SSRIs, MAOIs, or triptans
-
CNS depressants (alcohol, benzodiazepines) may enhance sedative effects
-
May increase levels of phenytoin or carbamazepine
-
Caution with anticoagulants like warfarin
Contraindications:
-
Known hypersensitivity to Mirtazapine or any of its components
-
Concurrent use with or within 14 days of discontinuing MAO inhibitors
Side Effects:
-
Common: Drowsiness, weight gain, increased appetite, dry mouth, dizziness
-
Less common: Edema, abnormal dreams, constipation, hypotension
-
Rare but serious: Blood dyscrasias (e.g., neutropenia), suicidal thoughts (especially in young adults), serotonin syndrome
Pregnancy & Lactation:
Should be used during pregnancy only if clearly necessary. Use with caution during breastfeeding as it may pass into breast milk. Always consult a physician.
Precautions & Warnings:
-
Monitor mood, behavior, and suicidal tendencies especially in initial weeks
-
Caution in elderly patients and those with hepatic or renal impairment
-
May impair alertness; avoid driving or operating heavy machinery
-
Gradual dose tapering is recommended during discontinuation
Therapeutic Class:
Atypical antidepressants; Noradrenergic and specific serotonergic antidepressants (NaSSAs)
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
.jpg)
Change Language