Olmezest AM 20 mg is a combination medication that contains two active ingredients: Olmesartan Medoxomil (20 mg) and Amlodipine (5 mg). Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that works by relaxing blood vessels, thus lowering blood pressure and reducing the risk of stroke, heart attack, and kidney damage. Amlodipine is a calcium channel blocker that helps to relax and widen blood vessels by preventing calcium from entering smooth muscle cells, which helps to lower blood pressure and reduce the strain on the heart. This medication is commonly prescribed for patients with hypertension (high blood pressure) who may require a combination therapy for better management of their condition. By combining these two drugs, Olmezest AM effectively manages blood pressure, improving cardiovascular health and reducing the risk of complications associated with hypertension. It is typically taken once daily, with or without food.