Description
Description:
Diplin M 500 mg Tablet is a combination medication containing Linagliptin (2.5 mg) and Metformin Hydrochloride (500 mg), produced by Navana Pharmaceuticals Ltd. It is primarily indicated for the management of type 2 diabetes mellitus in adults, particularly when diet and exercise alone are insufficient to achieve adequate glycemic control. Linagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, enhances the levels of incretin hormones, leading to increased insulin secretion and decreased glucagon release in a glucose-dependent manner. Metformin, a biguanide, works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity. This combination therapy offers a dual mechanism to effectively control blood sugar levels. The typical dosage is one tablet twice daily, preferably with meals, to minimize gastrointestinal side effects. However, it is contraindicated in patients with renal impairment, metabolic acidosis, or hypersensitivity to either component. Common side effects may include nasopharyngitis and diarrhea.
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