Description
Nabuton 500 mg is a non-steroidal anti-inflammatory drug (NSAID) manufactured by Navana Pharmaceuticals Ltd., containing Nabumetone as its active ingredient. Nabumetone is a prodrug that undergoes hepatic conversion to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which inhibits cyclooxygenase (COX) enzymes, leading to reduced production of prostaglandins responsible for inflammation, pain, and fever. Nabuton 500 mg is primarily used for the relief of symptoms associated with osteoarthritis and rheumatoid arthritis, including pain, stiffness, and swelling. The recommended starting dose for adults is 1000 mg per day, which may be increased to a maximum of 2000 mg per day based on individual patient response. It is advised to take Nabuton with food to minimize gastrointestinal discomfort. Special caution is required in patients with renal impairment, and dosage adjustments may be necessary. Contraindications include known hypersensitivity to Nabumetone or other NSAIDs, as well as conditions such as severe renal impairment, peptic ulcers, and perioperative pain following coronary artery bypass graft (CABG) surgery. Common side effects may include gastrointestinal disturbances, dizziness, and headache. As with all NSAIDs, long-term use should be under medical supervision to monitor for potential adverse effects.
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