Description
: Neumir 5 mg is a prescription medication manufactured by Navana Pharmaceuticals Ltd., containing Mirogabalin Besylate as its active ingredient. It is primarily used to manage various types of neuropathic pain, including diabetic peripheral neuropathic pain (DPNP), postherpetic neuralgia (PHN), and other peripheral neuropathic pain conditions. Mirogabalin, the active substance, selectively binds to the α₂δ subunits of voltage-gated calcium channels in the central nervous system. This binding reduces calcium influx and inhibits neurotransmitter release, thereby decreasing neuronal hyperexcitability and alleviating pain. The typical starting dose for adults is 5 mg twice daily, which may be gradually increased to a maximum of 15 mg twice daily, depending on the patient's response and tolerability. For patients with renal impairment, dose adjustments are necessary:
-
Mild renal dysfunction: Start with 5 mg twice daily, increasing to 10 mg twice daily.
-
Moderate renal dysfunction: Start with 2.5 mg twice daily, increasing to 7.5 mg twice daily.
-
Severe renal dysfunction: Start with 2.5 mg once daily, increasing to 7.5 mg once daily.
Common side effects may include dizziness, somnolence (sleepiness), edema (swelling), and weight gain. Patients should be cautious when engaging in activities that require alertness, such as driving, due to the potential for dizziness and drowsiness. The safety and efficacy of Neumir in children and adolescents have not been established. As with any medication, it is essential to follow the prescribed dosage and consult a healthcare provider before starting or adjusting treatment.
Change Language