Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Type 2 Diabetes Mellitus in adults
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Especially for overweight patients where diet, exercise, and monotherapy do not provide adequate glycemic control
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Can be used as initial therapy or as step-up therapy
Pharmacology:
This combination contains:
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Glimepiride: A sulfonylurea that stimulates insulin secretion from the pancreatic beta cells.
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Metformin: A biguanide that decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity.
Together, they work synergistically to maintain blood glucose levels in patients with type 2 diabetes.
Dosage:
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Common dose: 1 mg Glimepiride + 500 mg Metformin once or twice daily
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Dosage should be individualized based on blood glucose response
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Maximum dose should not exceed Glimepiride 8 mg and Metformin 2000 mg per day
Administration:
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Take with meals to reduce gastrointestinal side effects
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Swallow whole with water
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Maintain regular mealtime and physical activity
Interaction:
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Increased hypoglycemia risk with NSAIDs, insulin, MAOIs, beta-blockers
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Decreased Metformin effect with corticosteroids, diuretics, and estrogen
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Alcohol may increase risk of lactic acidosis
Contraindications:
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Type 1 diabetes
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Diabetic ketoacidosis
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Severe renal or hepatic impairment
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Congestive heart failure
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History of lactic acidosis
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Pregnancy and lactation
Side Effects:
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Hypoglycemia
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Nausea, vomiting
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Diarrhea
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Abdominal discomfort
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Metallic taste
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Rare: Lactic acidosis (from Metformin), blood disorders, hepatic dysfunction
Pregnancy & Lactation:
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Contraindicated in pregnancy; use insulin instead
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Should be avoided during breastfeeding
Precautions & Warnings:
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Monitor renal function regularly
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Risk of hypoglycemia—avoid skipping meals
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Be cautious in elderly and malnourished patients
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Educate patients on recognizing lactic acidosis symptoms: muscle pain, weakness, rapid breathing
Therapeutic Class:
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Oral Antidiabetic Combination
(Sulfonylurea + Biguanide)
Storage Conditions:
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Store in a cool, dry place below 30°C
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Protect from light and moisture
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Keep out of reach of children
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