Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Rheumatoid arthritis
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Osteoarthritis
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Ankylosing spondylitis
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Chronic musculoskeletal pain
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Gout and other inflammatory joint diseases
Pharmacology:
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the cyclooxygenase (COX) enzymes, reducing the formation of prostaglandins which mediate inflammation, pain, and fever. The sustained-release (SR) formulation provides a prolonged therapeutic effect and improved patient compliance.
Dosage & Administration:
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Usual adult dose: 75 mg once or twice daily, depending on the severity of symptoms
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Take with meals or milk to reduce gastrointestinal discomfort
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Do not crush or chew the capsule; swallow whole with water
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Dose should be adjusted by a physician as per individual response
Interaction:
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Caution with anticoagulants (e.g., warfarin) due to increased bleeding risk
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May reduce the effectiveness of antihypertensive agents
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Increased nephrotoxicity risk with ACE inhibitors, diuretics, or other NSAIDs
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Avoid concomitant use with other NSAIDs
Contraindications:
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Hypersensitivity to indomethacin or any NSAID
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Active or history of peptic ulcer or GI bleeding
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Severe hepatic, renal, or cardiac dysfunction
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Asthma triggered by aspirin or NSAIDs
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Perioperative pain in CABG surgery
Side Effects:
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Common: Heartburn, abdominal discomfort, headache, dizziness
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Serious: GI bleeding or ulcer, elevated liver enzymes, kidney impairment, cardiovascular events
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CNS: Drowsiness, confusion, especially in elderly
Pregnancy & Lactation:
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Pregnancy: Avoid, particularly in third trimester due to risk of fetal harm
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Lactation: Use with caution; consult a doctor before breastfeeding
Precautions & Warnings:
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Use lowest effective dose for shortest possible time
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Regular monitoring of liver and kidney function during prolonged therapy
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Increased risk of cardiovascular thrombotic events with long-term use
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Caution advised in elderly and patients with pre-existing GI or cardiac conditions
Therapeutic Class:
NSAIDs – Non-Steroidal Anti-Inflammatory Drugs (Sustained-Release Formulation)
Storage Conditions:
Store below 30°C, in a cool and dry place. Protect from direct sunlight and moisture. Keep out of reach of children.
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