Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Hypertension (high blood pressure)
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Diabetic nephropathy in type 2 diabetes
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Heart failure (in patients intolerant to ACE inhibitors)
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To reduce the risk of stroke in hypertensive patients with left ventricular hypertrophy
Pharmacology:
Losartan is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to the AT1 receptor, resulting in vasodilation, reduced secretion of vasopressin, and reduced production and secretion of aldosterone — leading to lowered blood pressure and reduced workload on the heart.
Dosage & Administration:
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Adults (hypertension): 50 mg once daily; may be increased to 100 mg/day
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Diabetic nephropathy: Initial dose 50 mg once daily, may increase to 100 mg
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Can be taken with or without food
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Dosage should be adjusted based on patient response and tolerability
Interaction:
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May increase serum potassium levels when taken with potassium-sparing diuretics or supplements
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NSAIDs may reduce the antihypertensive effect
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Risk of lithium toxicity if taken with lithium
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Avoid combination with aliskiren in diabetic patients
Contraindications:
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Hypersensitivity to Losartan or any component of the formulation
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Pregnancy (especially 2nd and 3rd trimester)
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Severe hepatic impairment
Side Effects:
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Common: Dizziness, fatigue, upper respiratory infections, nasal congestion
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Serious: Hypotension, hyperkalemia, renal impairment, angioedema (rare)
Pregnancy & Lactation:
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Pregnancy: Contraindicated, especially in second and third trimesters due to risk of fetal injury or death
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Lactation: Not recommended; unknown whether losartan is excreted in breast milk
Precautions & Warnings:
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Monitor renal function and potassium levels
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Caution in patients with hepatic impairment or volume depletion
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Avoid during pregnancy
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May cause symptomatic hypotension, especially after first dose in volume-depleted patients
Therapeutic Class:
Angiotensin-II Receptor Blockers (ARBs)
Storage Conditions:
Store below 30°C, away from moisture and direct sunlight. Keep out of reach of children.
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