Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Type 2 Diabetes Mellitus (especially in overweight patients)
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Can be used as monotherapy or in combination with other antidiabetic agents or insulin
Pharmacology:
Metformin is a biguanide that decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage & Administration:
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Usual starting dose: 850 mg once daily with meals
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Maximum recommended dose: 2550 mg/day in divided doses
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Should be taken with or after meals to minimize gastrointestinal discomfort
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Dose should be adjusted based on glycemic response
Interaction:
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Alcohol increases the risk of lactic acidosis
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May interact with iodine-containing contrast media
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Concomitant use with insulin or sulfonylureas may increase hypoglycemic effect
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Certain antihypertensive drugs and corticosteroids may affect blood sugar levels
Contraindications:
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Renal impairment (eGFR <30 mL/min/1.73 m²)
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
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Hypersensitivity to metformin
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Conditions predisposing to hypoxia (e.g., congestive heart failure)
Side Effects:
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Common: Nausea, vomiting, diarrhea, abdominal pain, loss of appetite
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Rare but serious: Lactic acidosis (a medical emergency)
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Long-term use may reduce vitamin B12 levels
Pregnancy & Lactation:
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Pregnancy: Usually insulin is preferred; metformin may be used if deemed appropriate
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Lactation: Excreted in breast milk in small amounts; generally considered safe
Precautions & Warnings:
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Monitor renal function regularly
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Avoid excessive alcohol intake
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Should be temporarily discontinued before surgery or use of contrast agents
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Not for use in Type 1 diabetes or diabetic ketoacidosis
Therapeutic Class:
Biguanide group – Oral Antidiabetic Agent
Storage Conditions:
Store below 30°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.
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