Description
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পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Type 2 diabetes mellitus (non-insulin dependent diabetes)
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Used when blood glucose is not adequately controlled with diet and exercise alone
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Helps control blood sugar levels and reduce long-term complications such as neuropathy, retinopathy, and nephropathy in diabetics
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Suitable for patients who require both an insulin secretagogue (glimepiride) and an insulin sensitizer (metformin)
Pharmacology:
Glimepiride, a sulfonylurea, stimulates insulin release from the pancreas and increases insulin sensitivity in tissues, thereby lowering blood glucose levels. Metformin is a biguanide that works by decreasing hepatic glucose production and increasing insulin sensitivity in muscle and adipose tissues. Together, these two medications provide a dual mechanism to control blood sugar effectively in type 2 diabetes.
Dosage & Administration:
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The usual starting dose is 1 mg of glimepiride and 500 mg of metformin, taken once daily with the first meal of the day.
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Dosage can be gradually increased depending on blood glucose levels, but the maximum dose should not exceed 4 mg of glimepiride and 2000 mg of metformin per day.
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Take the medication with food to reduce the risk of stomach upset.
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Always follow the prescribed dosage and monitor blood glucose regularly.
Interaction:
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Increased Effect: Alcohol, other antidiabetic medications, or drugs affecting liver enzymes can increase the blood-sugar-lowering effect of Amaryl M.
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Decreased Effect: Certain diuretics, corticosteroids, and beta-blockers may reduce its effectiveness.
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Metformin-related Interactions: Be cautious when combining with other drugs that affect kidney function, as metformin can accumulate and lead to lactic acidosis in patients with kidney dysfunction.
Contraindications:
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Hypersensitivity to glimepiride, metformin, or any components of the medication
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Type 1 diabetes mellitus (insulin-dependent diabetes)
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Diabetic ketoacidosis
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Severe liver or kidney disease
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History of lactic acidosis
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Pregnancy and breastfeeding (unless specifically prescribed by a healthcare provider)
Side Effects:
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Most common side effects include:
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Hypoglycemia (low blood sugar)
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Gastrointestinal upset (nausea, vomiting, diarrhea, abdominal discomfort)
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Weight gain
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Rare side effects include:
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Lactic acidosis (due to metformin)
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Skin rashes or allergic reactions
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Liver dysfunction (evidenced by jaundice)
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Blood disorders such as anemia or low white blood cell count
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Pregnancy & Lactation:
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Pregnancy: Not recommended during pregnancy, as insulin is generally preferred for managing diabetes during pregnancy.
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Lactation: Not recommended during breastfeeding, as both glimepiride and metformin may pass into breast milk. Consult your doctor before using.
Therapeutic Class:
Combination Oral Hypoglycemic Agents, Sulfonylureas and Biguanides
Storage Conditions:
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Store at room temperature (15°C to 30°C).
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Keep away from light, heat, and moisture.
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Keep out of the reach of children.
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