METSA XR 500 MG

METSA XR 500 MG

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Product Code : 120419643000501

Short Description

Metsa XR 500 MG is an extended-release tablet containing Metronidazole, used for treating anaerobic bacterial and protozoal infections with sustained action.

Name	Brand	Generic Name	Strength	PPF	Price
METSA XR 500 MG	SYNOVIA PHARMA PLC	METFORMIN HYDROCHLORIDE	500 mg	TABLET	7

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Pharmacology:

Metsa XR contains Metronidazole in an extended-release (XR) formulation.
It works by entering the microbial cell and generating free radicals that damage DNA, leading to the death of anaerobic bacteria and protozoa.
The extended-release form provides sustained plasma concentration, allowing less frequent dosing and improved compliance.

Dosage:

Common adult dose: 500 mg once or twice daily, based on the infection severity.
Duration: Typically 5–10 days, but should be determined by a physician.
Do not crush or chew the tablet as it may interfere with extended-release mechanism.

Administration:

Take the tablet orally, preferably with food to minimize gastrointestinal discomfort.
Swallow whole with water.
Maintain a regular dosing schedule for effective treatment.

Interaction:

Avoid alcohol during and 48 hours after treatment to prevent disulfiram-like reactions.
Can interact with:
- Warfarin – may increase bleeding risk
- Cimetidine – may raise metronidazole levels
- Enzyme-inducing drugs like phenytoin – may lower effectiveness
- Lithium – risk of lithium toxicity

Contraindications:

Known hypersensitivity to Metronidazole or related nitroimidazole compounds
History of blood disorders or CNS disorders (e.g., epilepsy)
Caution in severe liver disease

Side Effects:

Common: Nausea, metallic taste, dizziness, headache, diarrhea
Rare: Peripheral neuropathy (prolonged use), dark urine, allergic skin reactions
Serious: Seizures, encephalopathy (very rare)

Pregnancy & Lactation:

Pregnancy: Use in 1st trimester should be avoided unless necessary. In 2nd/3rd trimesters, use only if clearly needed (Category B).
Lactation: Metronidazole is secreted in breast milk. Either avoid breastfeeding during treatment or consult a physician for alternatives.

Therapeutic Class: