Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Pharmacology:
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Metronidazole is a nitroimidazole antimicrobial agent that is selectively toxic to anaerobic organisms and protozoa.
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Once inside anaerobic cells, it is reduced to active metabolites that bind DNA and inhibit nucleic acid synthesis, leading to microbial cell death.
Dosage:
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Adult dosage: 850 mg 2-3 times daily, depending on infection severity and type.
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Dosage and duration should be guided strictly by physician recommendation.
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Renal and hepatic impairment may require dose adjustment.
Administration:
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Take orally with a full glass of water.
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Can be taken with or after meals to reduce gastrointestinal discomfort.
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Complete the full course even if symptoms improve early.
Interaction:
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Do not consume alcohol during and for 48 hours after treatment – risk of disulfiram-like reaction (nausea, vomiting, cramps).
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Can interact with:
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Warfarin – increased bleeding risk
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Lithium – risk of toxicity
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Enzyme inducers like phenytoin, phenobarbital – reduced efficacy
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Cimetidine – may increase plasma metronidazole levels
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Contraindications:
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Hypersensitivity to Metronidazole or other nitroimidazoles
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History of blood dyscrasias or central nervous system disorders
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Use with caution in patients with hepatic encephalopathy or epilepsy
Side Effects:
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Common: Nausea, metallic taste, dry mouth, dizziness, headache
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Less common: Diarrhea, loss of appetite, dark urine
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Serious (rare): Neuropathy, seizures, allergic reactions, pancreatitis
Pregnancy & Lactation:
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Pregnancy: Category B – use only if clearly needed, especially avoiding first trimester for trichomoniasis treatment
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Lactation: Metronidazole is excreted in breast milk. Consider pausing breastfeeding or consulting a physician for risk assessment
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