Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Type 2 diabetes mellitus (non-insulin dependent diabetes)
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Used in patients whose blood glucose is not adequately controlled by diet and exercise alone
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Helps control blood sugar and reduce the risk of diabetic complications like neuropathy, retinopathy, and nephropathy
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Suitable for patients who need both insulin secretion enhancement (glimepiride) and insulin sensitivity improvement (metformin)
Pharmacology:
Glimepiride, a sulfonylurea, increases insulin secretion from the pancreas and enhances insulin sensitivity in peripheral tissues. Metformin, a biguanide, works by reducing glucose production in the liver and improving insulin sensitivity in muscle and adipose tissue. The combination of these two agents offers a dual mechanism to control blood sugar in patients with type 2 diabetes.
Dosage & Administration:
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The typical starting dose is 1 mg of glimepiride and 500 mg of metformin, taken once daily with the first meal of the day.
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The dose may be gradually increased depending on blood glucose control, but the maximum dose should not exceed 4 mg of glimepiride and 2000 mg of metformin per day.
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Take the medication with food to reduce gastrointestinal side effects like nausea and upset stomach.
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Always follow the prescribed dosage and monitor blood glucose regularly.
Interaction:
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Increased Effect: Alcohol, other antidiabetic drugs, or drugs that affect liver enzymes can enhance the blood-sugar-lowering effects of Amaryl M.
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Decreased Effect: Certain drugs, such as corticosteroids, diuretics, and beta-blockers, may reduce its effectiveness.
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Metformin-related Interactions: Be cautious when combining with drugs affecting kidney function, as metformin can accumulate and increase the risk of lactic acidosis in patients with impaired renal function.
Contraindications:
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Hypersensitivity to glimepiride, metformin, or any component of the medication
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Type 1 diabetes mellitus (insulin-dependent diabetes)
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Diabetic ketoacidosis
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Severe liver or kidney disease
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History of lactic acidosis
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Pregnancy and breastfeeding (unless prescribed by a healthcare provider)
Side Effects:
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Most common side effects include:
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Hypoglycemia (low blood sugar)
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Gastrointestinal upset (nausea, vomiting, diarrhea, abdominal discomfort)
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Weight gain
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Less common but serious side effects:
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Lactic acidosis (due to metformin)
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Skin rashes or allergic reactions
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Liver dysfunction (indicated by jaundice)
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Blood disorders like anemia or low white blood cell count
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Pregnancy & Lactation:
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Pregnancy: Generally not recommended during pregnancy, as insulin is usually preferred for managing diabetes during pregnancy.
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Lactation: Not recommended during breastfeeding. Both glimepiride and metformin may pass into breast milk, and consulting a doctor is advised before use.
Therapeutic Class:
Combination Oral Hypoglycemic Agents, Sulfonylureas and Biguanides
Storage Conditions:
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Store at room temperature (15°C to 30°C).
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Keep away from light, moisture, and heat.
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Keep out of the reach of children.
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