Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
NIMOVO 500 mg is indicated for:
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Relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
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Decreasing the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers
Pharmacology:
NIMOVO 500 mg is a combination of two active ingredients:
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Naproxen: A non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It works by inhibiting prostaglandin synthesis, thereby reducing pain and inflammation.
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Esomeprazole: A proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase in the gastric parietal cells, reducing stomach acidity and protecting the gastric mucosa from NSAID-induced damage.
Dosage & Administration:
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Adults: One tablet twice daily (morning and evening), at least 30 minutes before meals.
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Administration: Swallow the tablet whole; do not chew, crush, or dissolve.
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Note: Use the lowest effective dose for the shortest duration consistent with individual treatment goals.
Interaction:
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With other medications:
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Concomitant use with ACE inhibitors, diuretics, and beta-blockers may reduce their antihypertensive effects.
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Co-administration with warfarin may increase the risk of bleeding.
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Esomeprazole may interfere with the absorption of drugs like ketoconazole, iron salts, and digoxin due to altered gastric pH.
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With food:
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Taking NIMOVO with high-fat meals may delay the absorption of Naproxen but does not significantly affect its overall absorption.
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Contraindications:
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Known hypersensitivity to Naproxen, Esomeprazole, or any component of this product.
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History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
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Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Side Effects:
Common:
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Gastrointestinal discomfort, nausea, vomiting, diarrhea, indigestion, flatulence, abdominal pain.
Serious: -
Gastrointestinal bleeding, peptic ulcers, perforation, cardiovascular events (e.g., myocardial infarction, stroke), renal impairment, liver dysfunction, skin reactions.
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Long-term use may lead to vitamin B12 deficiency and fundic gland polyps.
Pregnancy & Lactation:
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Pregnancy: Contraindicated during the third trimester. Use only if the potential benefit justifies the potential risk to the fetus during the first and second trimesters.
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Lactation: Not recommended during breastfeeding due to the presence of Naproxen.
Precautions & Warnings:
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Use with caution in patients with a history of gastrointestinal disease, cardiovascular disease, hypertension, renal or hepatic impairment.
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Monitor for signs of gastrointestinal bleeding, cardiovascular events, and renal function during treatment.
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Avoid concurrent use with other NSAIDs or anticoagulants unless directed by a healthcare provider.
Therapeutic Class:
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Non-steroidal anti-inflammatory drugs (NSAIDs)
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Proton pump inhibitors
Storage Conditions:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
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