Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Obsessive-Compulsive Disorder (OCD)
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Major depressive disorder
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Panic disorder
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Phobic states
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Chronic painful conditions
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Cataplexy associated with narcolepsy
Pharmacology:
Clomipramine, a tricyclic antidepressant, inhibits the reuptake of serotonin and norepinephrine in the brain, enhancing neurotransmitter activity and improving mood and behavior in patients with depression or OCD.
Dosage & Administration:
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Adults: Usually 25 mg 2–3 times daily, gradually increased if needed
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Maintenance dose: Often 50–75 mg daily
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Should be taken with food to reduce gastric irritation
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Dosage should be individualized and gradually adjusted
Interaction:
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Increased risk of serotonin syndrome with SSRIs and MAOIs
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Enhances the effects of CNS depressants and alcohol
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May interact with anticholinergic agents, antihypertensives, and anticoagulants
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Caution with QT-prolonging drugs
Contraindications:
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Recent myocardial infarction
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Concurrent use with monoamine oxidase inhibitors (MAOIs)
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Hypersensitivity to clomipramine or other tricyclic antidepressants
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History of seizures
Side Effects:
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Common: Dry mouth, constipation, drowsiness, dizziness, blurred vision
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Less common: Weight gain, sexual dysfunction, urinary retention
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Rare: Cardiac arrhythmias, seizures, confusion (especially in elderly)
Pregnancy & Lactation:
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Pregnancy: Use only if clearly needed; may pose risk in the third trimester
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Lactation: Excreted in breast milk; use with caution
Precautions & Warnings:
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Monitor for suicidal thoughts, especially in early treatment
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Caution in patients with cardiovascular disease, epilepsy, glaucoma, and urinary retention
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Gradual withdrawal is advised to avoid discontinuation symptoms
Therapeutic Class:
Tricyclic antidepressants (TCA)
Storage Conditions:
Store below 25–30°C in a dry, cool place, away from light. Keep out of reach of children.
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