Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
Rimstar 4 FDC is indicated for the initial intensive phase treatment of tuberculosis (TB). It contains a fixed-dose combination of four essential antitubercular drugs, used to reduce the bacterial load quickly and prevent resistance.
Pharmacology
Rimstar 4 FDC combines Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol — each with a unique mechanism against Mycobacterium tuberculosis.
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Rifampicin inhibits bacterial RNA synthesis
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Isoniazid disrupts mycolic acid synthesis in the cell wall
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Pyrazinamide lowers intracellular pH, damaging TB bacteria
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Ethambutol interferes with cell wall formation by inhibiting arabinosyl transferase
Dosage & Administration
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Usually 4 tablets once daily, on an empty stomach, as per body weight
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Used for 2 months during the intensive phase of TB treatment
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Must be used in combination with continuation phase therapy
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Swallow whole with water; do not break or crush
Interaction
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Rifampicin reduces effectiveness of oral contraceptives, warfarin, antiretrovirals
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Isoniazid interacts with phenytoin, carbamazepine
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Alcohol increases hepatotoxicity risk
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Avoid antacids within 2 hours of taking the medicine
Contraindications
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Hypersensitivity to any component
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Severe liver disease
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Optic neuritis (due to ethambutol)
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Gout (caution with pyrazinamide)
Side Effects
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Common: Nausea, vomiting, fatigue, joint pain, red-orange urine
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Serious: Hepatitis, peripheral neuropathy, optic neuritis, rash, hyperuricemia
Pregnancy & Lactation
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Use in pregnancy only if clearly necessary
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Components pass into breast milk; generally considered safe with monitoring
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Pyridoxine supplementation recommended during pregnancy
Precautions & Warnings
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Monitor liver function and vision regularly
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Educate about urine discoloration (harmless)
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Supplement Vitamin B6 to prevent neuropathy
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Adherence is crucial to avoid resistance development
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Avoid alcohol
Therapeutic Class
Antitubercular fixed-dose combinations (4-drug regimen)
Storage Conditions
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
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