Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Galvus Met 50/500 mg is indicated for:
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Treatment of type 2 diabetes mellitus in adults
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Patients inadequately controlled with metformin monotherapy
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Patients currently receiving vildagliptin and metformin as separate tablets
Pharmacology:
Galvus Met combines two complementary agents:
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Vildagliptin: A DPP-4 inhibitor that improves glucose-dependent insulin secretion and suppresses glucagon secretion, enhancing overall glycemic control.
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Metformin: A biguanide that reduces hepatic glucose production, improves peripheral insulin sensitivity, and delays intestinal glucose absorption.
The dual mechanism offers synergistic action for better blood sugar regulation.
Dosage & Administration:
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Typically, one tablet (50/500 mg) taken twice daily with meals
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Individualize the dose based on patient’s current regimen, tolerance, and response
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Not recommended for patients with moderate to severe renal impairment
Interaction:
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Alcohol intake increases the risk of lactic acidosis
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May interact with iodinated contrast materials, NSAIDs, and diuretics
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Potential for hypoglycemia when used with sulfonylureas or insulin
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Monitor blood glucose when used with beta-blockers
Contraindications:
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Hypersensitivity to vildagliptin, metformin, or any excipients
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Severe renal or hepatic impairment
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Metabolic acidosis or diabetic ketoacidosis
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Type 1 diabetes mellitus
Side Effects:
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Common: Nausea, diarrhea, headache, dizziness
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Less common: Flatulence, taste disturbance, mild hypoglycemia
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Rare: Lactic acidosis, hepatic dysfunction, pancreatitis
Pregnancy & Lactation:
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Pregnancy: Use only if clearly necessary and under medical supervision
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Lactation: Not recommended due to limited data on excretion into breast milk
Precautions & Warnings:
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Monitor renal and liver function periodically
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Discontinue if signs of lactic acidosis appear (e.g., fatigue, rapid breathing, muscle pain)
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Avoid excessive alcohol consumption
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Not suitable for type 1 diabetes or for treating diabetic ketoacidosis
Therapeutic Class:
Oral Antidiabetic – DPP-4 Inhibitor & Biguanide Combination
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
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