Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
Rimactazid 300mg is indicated for the treatment and prevention of all forms of tuberculosis (TB), particularly in patients who require a combination of rifampicin and isoniazid.
Pharmacology
Rimactazid is a fixed-dose combination of rifampicin and isoniazid. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing RNA synthesis. Isoniazid interferes with the synthesis of mycolic acid, essential for mycobacterial cell wall formation. The combination provides synergistic bactericidal activity against Mycobacterium tuberculosis.
Dosage & Administration
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Dose depends on body weight and treatment stage.
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Common adult dose: 1 tablet daily on an empty stomach, ideally in the morning.
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Should be used as part of a full anti-TB regimen.
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Do not skip doses or stop treatment prematurely.
Interaction
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Rifampicin induces hepatic enzymes, which can reduce the efficacy of oral contraceptives, warfarin, corticosteroids, and some antiretrovirals.
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Avoid alcohol to reduce liver toxicity risks.
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Isoniazid may increase levels of phenytoin and carbamazepine.
Contraindications
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Hypersensitivity to rifampicin, isoniazid, or other rifamycins.
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Severe hepatic dysfunction.
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History of drug-induced hepatitis.
Side Effects
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Common: Nausea, vomiting, red-orange discoloration of urine, fatigue, rash.
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Serious: Hepatotoxicity, peripheral neuropathy, hypersensitivity reactions, thrombocytopenia.
Pregnancy & Lactation
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Use in pregnancy only when benefits outweigh risks; rifampicin may increase bleeding tendency.
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Both rifampicin and isoniazid pass into breast milk but are generally considered safe during lactation.
Precautions & Warnings
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Monitor liver function before and during therapy.
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Supplement vitamin B6 (pyridoxine) to reduce neuropathy risk.
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Advise patients of urine and body fluid discoloration.
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Ensure adherence to full TB regimen to prevent resistance.
Therapeutic Class
Antitubercular fixed-dose combinations
Storage Conditions
Store below 25°C in a dry place, protected from light. Keep out of reach of children.
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