Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
Rimactazid 450mg is indicated for the treatment of pulmonary and extrapulmonary tuberculosis, especially in patients requiring combination therapy with rifampicin and isoniazid.
Pharmacology
Rimactazid 450mg contains two potent antitubercular agents: rifampicin and isoniazid. Rifampicin inhibits bacterial RNA synthesis by targeting DNA-dependent RNA polymerase. Isoniazid blocks the synthesis of mycolic acids in the bacterial cell wall. Together, they provide effective bactericidal action against Mycobacterium tuberculosis.
Dosage & Administration
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Adults: Dose depends on body weight and treatment stage
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Usual dose: 1 tablet daily on an empty stomach, preferably in the morning
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Should be used as part of a complete anti-TB regimen
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Adherence to full course is essential to avoid resistance
Interaction
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Rifampicin may reduce the effectiveness of oral contraceptives, anticoagulants, and antiretrovirals
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Isoniazid may enhance levels of phenytoin, carbamazepine, and other drugs
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Avoid alcohol due to risk of hepatotoxicity
Contraindications
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Known hypersensitivity to rifampicin, isoniazid, or other components
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Active liver disease or history of drug-induced hepatitis
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Severe hepatic dysfunction
Side Effects
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Common: Nausea, vomiting, red-orange discoloration of body fluids, loss of appetite
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Serious: Hepatitis, peripheral neuropathy, allergic reactions, blood disorders
Pregnancy & Lactation
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Use only if clearly needed during pregnancy
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Rifampicin may increase bleeding risks in neonates
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Both ingredients are excreted in breast milk; caution is advised
Precautions & Warnings
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Regular liver function monitoring is essential
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Pyridoxine (vitamin B6) supplementation is recommended to prevent neuropathy
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Educate patients on harmless discoloration of urine and other fluids
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Avoid interruption of therapy to prevent resistance
Therapeutic Class
Antitubercular fixed-dose combinations
Storage Conditions
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of the reach of children.
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