Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
Probitor 40mg is indicated for the treatment of gastroesophageal reflux disease (GERD), gastric and duodenal ulcers, Zollinger-Ellison syndrome, and erosive esophagitis.
Pharmacology
Probitor 40mg contains Omeprazole, a proton pump inhibitor (PPI). It works by irreversibly inhibiting the H+/K+ ATPase enzyme in the gastric parietal cells, significantly reducing stomach acid secretion.
Dosage & Administration
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Adults: 20–40 mg once daily before meals
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GERD & Ulcers: Typically 4–8 weeks of therapy
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Swallow whole with water; do not crush or chew
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Dose adjustments may be required in certain conditions
Interaction
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May reduce absorption of drugs like ketoconazole, atazanavir, and iron salts
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May enhance the effect of warfarin, diazepam, and phenytoin
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Avoid concurrent use with clopidogrel unless necessary
Contraindications
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Known hypersensitivity to omeprazole or other PPIs
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Not recommended in patients with severe hepatic impairment without monitoring
Side Effects
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Common: Headache, nausea, abdominal pain, constipation, flatulence
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Rare: Vitamin B12 deficiency, hypomagnesemia, skin rash, dizziness
Pregnancy & Lactation
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Pregnancy: Category C; use only if clearly needed and prescribed
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Lactation: Omeprazole is excreted in breast milk; consult a physician before use
Precautions & Warnings
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Long-term use may increase the risk of bone fractures, C. difficile infection, and B12 deficiency
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Monitor magnesium levels for prolonged use
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Use caution in elderly and patients with liver problems
Therapeutic Class
Proton Pump Inhibitors (PPIs)
Storage Conditions
Store in a cool, dry place below 25°C. Keep away from light and moisture. Keep out of reach of children.
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