Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Treatment of chronic heart failure with reduced ejection fraction (HFrEF)
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Reduces risk of cardiovascular death and heart failure hospitalization
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Improves symptoms and quality of life in heart failure patients
Pharmacology:
Entresto combines:
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Sacubitril: Neprilysin inhibitor that increases natriuretic peptides causing vasodilation and diuresis
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Valsartan: Angiotensin II receptor blocker that lowers blood pressure and reduces heart strain
This dual action helps improve heart efficiency and reduces fluid retention.
Dosage & Administration:
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Usually started at 100 mg twice daily, adjusted as per patient tolerance and renal function
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May be taken with or without food
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Requires 36-hour washout period after ACE inhibitor therapy before starting Entresto
Interaction:
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Avoid use with ACE inhibitors due to risk of angioedema
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Monitor potassium levels when used with potassium-sparing agents
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Potential interactions with NSAIDs, lithium, and other antihypertensives
Contraindications:
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History of angioedema related to ACE inhibitors or ARBs
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Concurrent use with ACE inhibitors
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Pregnancy and breastfeeding
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Severe hepatic impairment
Side Effects:
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Common: Hypotension, dizziness, hyperkalemia, cough
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Less common: Renal impairment, angioedema, fatigue
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Rare: Serious allergic reactions
Pregnancy & Lactation:
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Pregnancy: Contraindicated due to fetal risk
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Lactation: Not recommended
Precautions & Warnings:
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Regularly monitor blood pressure, renal function, and electrolytes
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Educate patients to report angioedema symptoms immediately
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Use caution in patients with renal impairment or hypotension
Therapeutic Class:
Angiotensin receptor neprilysin inhibitor (ARNI)
Storage Conditions:
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
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