Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Comet® is indicated for:
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Management of type 2 diabetes mellitus, especially in overweight patients
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Improving glycemic control when diet and exercise alone are insufficient
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May be used alone or in combination with other antidiabetic agents
Pharmacology:
Metformin decreases hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization, resulting in better glycemic control without causing hypoglycemia.
Dosage & Administration:
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Adults: Usually start with 500 mg once or twice daily, may increase up to 2000 mg/day based on tolerance and response.
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Take with meals to reduce gastrointestinal side effects.
Interaction:
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May interact with cimetidine, iodinated contrast agents, and other drugs affecting renal function.
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Alcohol increases risk of lactic acidosis.
Contraindications:
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Renal impairment or dysfunction
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Metabolic acidosis including diabetic ketoacidosis
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Hypersensitivity to Metformin
Side Effects:
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Common: gastrointestinal disturbances (nausea, vomiting, diarrhea)
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Rare but serious: lactic acidosis
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Vitamin B12 deficiency with long-term use
Pregnancy & Lactation:
Use during pregnancy only if clearly needed. Consult doctor before use during breastfeeding.
Precautions & Warnings:
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Monitor renal function periodically
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Avoid alcohol consumption
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Use caution in elderly and in patients with hepatic impairment
Therapeutic Class:
Oral hypoglycemic agent (Biguanide)
Storage Conditions:
Store below 30°C in a dry place. Protect from moisture and light. Keep out of reach of children.
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