Nexum 20 mg Capsule

Nexum 20 mg Capsule

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Product Code : 121410709602301

Short Description Proton pump inhibitor reducing stomach acid for GERD, erosive esophagitis, ulcers, and Zollinger–Ellison syndrome.

Name	Brand	Generic Name	Strength	PPF	Price
Nexum 20 mg Capsule	SQUARE PHARMACEUTICALS LTD	ESOMEPRAZOLE	20 mg	Capsule	7.02

৳ 7.02

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Indications:

Gastroesophageal reflux disease (GERD), symptomatic and erosive esophagitis
Healing and maintenance of erosive esophagitis
Peptic (duodenal & gastric) ulcers, including NSAID-associated ulcers
H. pylori eradication (with amoxicillin + clarithromycin)
Zollinger–Ellison syndrome and other hypersecretory conditions

Pharmacology:
Esomeprazole is an irreversible proton pump inhibitor that suppresses gastric acid secretion by inhibiting H⁺/K⁺‑ATPase in parietal cells. As the S‑isomer of omeprazole, it offers more effective acid control.

Dosage & Administration:

Erosive esophagitis: 20–40 mg once daily for 4–8 weeks; may extend another 4–8 weeks if needed
Maintenance: 20 mg once daily (≤6 months)
Symptomatic GERD: 20 mg once daily for 4 weeks (may extend 4 more)
Duodenal ulcer: 20 mg daily for 2–4 weeks
Gastric ulcer & dyspepsia: 20–40 mg daily for 4–8 weeks
NSAID-associated ulcer: 20 mg daily for 4–8 weeks; risk reduction up to 6 months
H. pylori eradication: 40 mg once daily (esomeprazole) + amoxicillin 1000 mg + clarithromycin 500 mg twice daily for 7–10 days
Zollinger–Ellison: individually titrated, typically 20–80 mg daily, up to 240 mg if required
Pediatric dosing and IV regimens per clinical guidelines
Take at least one hour before meals; swallow whole without chewing.

Interaction:

Metabolized by CYP2C19 and CYP3A4; may interact with diazepam, warfarin, ketoconazole, iron, digoxin
Less impact with amoxicillin, clarithromycin directly, but esomeprazole levels slightly increased in triple therapy
Can prolong INR with warfarin; may reduce efficacy of clopidogrel

Contraindications:

Known hypersensitivity to esomeprazole or substituted benzimidazoles

Side Effects:
Common: headache, nausea, diarrhea, abdominal pain, flatulence, constipation, dry mouth, dizziness.
Serious: pneumonitis, Clostridioides difficile infection, angioedema, potential bone fracture risk, hypomagnesemia with long-term use.

Pregnancy & Lactation:
Category B3 in Australia; appears safe in pregnancy with no strong contraindications. Breastfeeding data limited; use only if necessary.

Precautions & Warnings: