Description
Ardance-L 10 mg + 5 mg Tablet is a fixed-dose combination medication containing two active ingredients: Empagliflozin (10 mg) and Linagliptin (5 mg). Empagliflozin is a Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor, while Linagliptin is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. This combination is primarily used to manage type 2 diabetes mellitus in adults, particularly when diet and exercise alone do not provide adequate glycemic control. Empagliflozin works by reducing glucose reabsorption in the kidneys, leading to increased glucose excretion through urine. Linagliptin enhances the activity of incretin hormones, which increases insulin release and decreases glucagon secretion in a glucose-dependent manner. Together, these mechanisms help improve overall blood sugar control. The recommended starting dose is 10 mg Empagliflozin and 5 mg Linagliptin once daily, taken in the morning with or without food. Depending on individual response, the dose may be increased to 25 mg Empagliflozin and 5 mg Linagliptin once daily. It is important to assess renal function before initiating this medication, as it is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 45 mL/min/1.73 m². Common side effects may include urinary tract infections, genital fungal infections, dehydration, and hypotension. As with any medication, it should be used under the guidance of a healthcare provider.
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