Duovas 5 mg/20 mg

Duovas 5 mg/20 mg

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Product Code : 118819603100401

Short Description

Duovas 5/20 mg is a combination of Amlodipine and Atorvastatin used for treating hypertension and high cholesterol.

Name	Brand	Generic Name	Strength	PPF	Price
Duovas 5 mg/20 mg	RADIANT DISTRIBUTIONS LTD		5 mg/20 mg	TABLET	13

৳ 13

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Indications:
Duovas is indicated for patients requiring concurrent treatment of hypertension and dyslipidemia. It helps reduce cardiovascular risk in patients with risk factors such as diabetes, coronary artery disease, or a history of stroke or myocardial infarction.

Pharmacology:

Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium ion influx in vascular smooth muscle and cardiac muscle. It lowers blood pressure by causing vasodilation.
Atorvastatin is an HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver, lowering total cholesterol, LDL-C, and triglycerides while modestly increasing HDL-C.

Dosage & Administration:

The usual adult dose is one tablet (5 mg Amlodipine + 20 mg Atorvastatin) once daily.
Dose adjustments may be required based on patient response, renal or hepatic function.
Can be taken with or without food, preferably at the same time each day.

Interaction:

Amlodipine: May interact with other antihypertensives, CYP3A4 inhibitors (e.g., diltiazem), and grapefruit juice.
Atorvastatin: May interact with antifungals (e.g., ketoconazole), macrolide antibiotics, cyclosporine, digoxin, and warfarin. Risk of myopathy increases with fibrates or niacin.

Contraindications:

Hypersensitivity to any component
Active liver disease or unexplained persistent elevation of liver enzymes
Pregnancy and lactation (especially due to statin component)
Severe hypotension, aortic stenosis, or cardiogenic shock

Side Effects:

Common: Headache, dizziness, ankle swelling (from Amlodipine); muscle pain, GI upset (from Atorvastatin)
Serious (rare): Rhabdomyolysis, liver enzyme elevation, allergic reactions, hypotension

Pregnancy & Lactation:
Contraindicated in pregnancy and during breastfeeding due to the Atorvastatin component. Statins can harm fetal development. Effective contraception is advised during use.

Precautions & Warnings: