Betabis Plus 5 mg is a combination tablet containing Bisoprolol Fumarate (5 mg) and Hydrochlorothiazide (6.25 mg), used primarily to manage hypertension (high blood pressure). Bisoprolol is a selective β₁-adrenergic blocker that reduces heart rate and myocardial contractility, thereby lowering blood pressure. Hydrochlorothiazide is a thiazide diuretic that helps reduce blood pressure by eliminating excess sodium and water from the body, which decreases blood volume. This combination therapy is particularly beneficial for patients whose blood pressure is inadequately controlled with monotherapy. The typical starting dose is one tablet daily, which may be adjusted based on the patient's response and tolerance. Common side effects include dizziness, fatigue, headache, and gastrointestinal disturbances. It is important to monitor kidney function, blood pressure, and electrolytes during treatment. Patients should use this medication under medical supervision to ensure its safety and efficacy.