Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
🔸 Indications:
Dulox 30 mg is indicated for:
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Major depressive disorder (MDD)
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Generalized anxiety disorder (GAD)
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Diabetic peripheral neuropathic pain
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Fibromyalgia
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Chronic musculoskeletal pain (e.g., back pain, osteoarthritis)
🔸 Pharmacology:
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It increases the levels of serotonin and norepinephrine in the central nervous system, helping improve mood and reduce pain signals.
🔸 Dosage:
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Depression & anxiety: Start with 30 mg once daily; may increase to 60 mg/day
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Neuropathic pain/fibromyalgia: 30–60 mg/day as per physician’s recommendation
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Dose adjustments required in liver/kidney impairment
🔸 Administration:
Take orally, with or without food. Swallow capsule whole; do not crush or chew.
🔸 Interaction:
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Avoid use with MAO inhibitors
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Caution with SSRIs, antiplatelets, anticoagulants (risk of bleeding)
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Interaction possible with CYP1A2 and CYP2D6 inhibitors
🔸 Contraindications:
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Hypersensitivity to Duloxetine
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Concurrent use with MAOIs
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Uncontrolled narrow-angle glaucoma
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Severe hepatic or renal impairment
🔸 Side Effects:
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Nausea
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Dry mouth
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Drowsiness or insomnia
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Dizziness
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Constipation
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Increased sweating
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Rare: suicidal thoughts in adolescents/young adults
🔸 Pregnancy & Lactation:
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Use only if clearly needed during pregnancy
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Not recommended during breastfeeding without medical advice
🔸 Precautions & Warnings:
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Monitor for worsening depression or suicidal behavior, especially at therapy initiation
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Risk of serotonin syndrome if combined with serotonergic drugs
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Taper dose gradually when discontinuing
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Use with caution in patients with seizure disorders, bipolar disorder, or hypertension
🔸 Therapeutic Class:
Antidepressant – SNRI (Serotonin-Norepinephrine Reuptake Inhibitor)
🔸 Storage Conditions:
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Store below 25°C
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Keep in a dry place, away from light and moisture
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Keep out of reach of children
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