Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Glustin TS is indicated for the treatment of osteoarthritis of knee, hip, spine, hand, and other locations as a dietary supplement. It is also beneficial in rheumatoid arthritis, sport injuries, migraine, different skin problems (e.g., psoriasis), vascular complications (e.g., atherosclerosis), kidney stones, and inflammatory bowel disease (e.g., ulcerative colitis, leaky gut syndrome).
Pharmacology:
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Glucosamine Sulfate: A natural amino-sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. GAGs bind with protein and form proteoglycans, the essential building block of articular cartilage. When cartilage in a joint deteriorates, osteoarthritis develops. It also helps to form ligaments, tendons, nails, and various other connective tissues. Supplementing with glucosamine sulfate increases glucosamine levels in the body, facilitating the production and repair of cartilage. Glucosamine also activates chondrocytes in the cartilage, which help produce GAGs and proteoglycans.
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Chondroitin Sulfate: A glycosaminoglycan (acid mucopolysaccharide) found in connective tissue, especially in the articular cartilage of all mammals. Chondroitin sulfate supplements act similarly to glucosamine sulfate, as they also provide substrates for proteoglycans. Chondroitin also protects existing healthy cartilage from premature decline by preventing the MMP (Matrix metalloproteinase) enzyme that breaks down proteoglycans.
Combining glucosamine with chondroitin sulfate shows a synergistic effect. Data supports that this combination has been shown to be very effective in severe cases of osteoarthritis, treating both signs and symptoms and modifying disease progression. It prevents osteoarthritis in normal adults. In osteoarthritic pain, it is as effective as NSAIDs with significantly better tolerability and clinical compliance. It is also helpful during the repair phase of musculoskeletal soft tissue injuries such as tendon or ligament strains.
Dosage:
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Adults:
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250/200 mg tablet: 1 to 2 tablets, three times daily. Dose may be adjusted according to the response of the drug and body weight. Doses can be tapered after 60 days as per the requirement of the individual and for cost convenience. Typical dosage recommendation, based on body weight is as follows:
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Under 54 kg: 1000 mg Glucosamine Sulfate & 800 mg Chondroitin Sulfate per day
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54 kg to 91 kg: 1500 mg Glucosamine Sulfate & 1200 mg Chondroitin Sulfate per day
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Over 91 kg: 2000 mg Glucosamine Sulfate & 1600 mg Chondroitin Sulfate per day
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750/600 mg tablet: 1 tablet two times daily or as directed by the physician.
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Administration:
Take one tablet orally twice daily, preferably during or after meals, to enhance absorption and reduce gastrointestinal discomfort.
Interaction:
There have been no reports of significant drug interactions of glucosamine and chondroitin with antibiotics, antidepressants, antihypertensives, nitrates, antiarrhythmics, anxiolytics, hypoglycemic agents, antisecretives, or antiasthmatics. However, chondroitin may enhance the blood-thinning effects of anticoagulants like warfarin and heparin.
Contraindications:
There are no known contraindications for glucosamine and chondroitin. However, proven hypersensitivity (e.g., allergic to shellfish or sulfur) to glucosamine and chondroitin is a contraindication.
Side Effects:
Safety studies with glucosamine sulfate and chondroitin sulfate show no demonstrable side effects. Rarely occurring side effects (such as mild and reversible intestinal flatulence) are almost like placebo.
Pregnancy & Lactation:
Women who are pregnant or who could become pregnant should not supplement with glucosamine sulfate or chondroitin sulfate. These substances have not been studied enough to determine their effects on a developing fetus. No studies have evaluated the use of glucosamine and chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy and lactation.
Therapeutic Class:
Stimulation of cartilage formation
Storage Conditions:
Store in a cool and dry place, protected from light.
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