Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
NEBIPRES 5MG is indicated for:
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Treatment of essential hypertension (high blood pressure).
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Adjunctive therapy in stable mild to moderate chronic heart failure in patients over 70 years of age.
Pharmacology:
NEBIPRES 5MG contains Nebivolol, a selective β1-adrenergic receptor blocker. It works by:
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Reducing heart rate and myocardial contractility.
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Diminishing sympathetic nervous system activity.
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Suppressing renin release.
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Inducing vasodilation through nitric oxide release, leading to decreased peripheral vascular resistance.
Dosage & Administration:
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Adults:
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Hypertension: Start with 5 mg once daily; may increase to a maximum of 40 mg once daily if needed.
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Chronic Heart Failure: Start with 1.25 mg once daily; may increase every 1–2 weeks if tolerated, up to a maximum of 10 mg once daily.
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Elderly Patients:
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Hypertension: Start with 2.5 mg once daily; may increase to 5 mg once daily if needed.
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Chronic Heart Failure: Start with 1.25 mg once daily; may increase as tolerated.
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Renal Impairment:
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CrCl <30 mL/min: Start with 2.5 mg once daily; may increase to 5 mg once daily if needed.
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Hepatic Impairment:
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Moderate: Start with 2.5 mg once daily; increase cautiously.
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Administration:
Take NEBIPRES 5MG orally, with or without food, as directed by your healthcare provider.
Interaction:
Use caution when co-administering with:
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CYP2D6 inhibitors (e.g., quinidine, propafenone, fluoxetine, paroxetine).
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Other β-blockers (e.g., nebivolol, propranolol).
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Calcium channel blockers (e.g., verapamil, diltiazem).
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Antiarrhythmic agents (e.g., disopyramide).
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Digitalis glycosides.
Contraindications:
Do not use NEBIPRES 5MG if you have:
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Severe bradycardia.
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Heart block greater than first degree.
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Cardiogenic shock.
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Decompensated heart failure.
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Sick sinus syndrome (unless a permanent pacemaker is in place).
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Severe hepatic impairment.
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Hypersensitivity to any component of this product.
Side Effects:
Common side effects may include:
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Headache.
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Nausea.
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Bradycardia (slow heart rate).
Pregnancy & Lactation:
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Pregnancy: Category C. Use only if clearly needed and prescribed by a healthcare provider.
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Lactation: Not recommended during breastfeeding.
Therapeutic Class:
Beta-adrenoceptor blocking drugs (Beta-blockers)
Storage Conditions:
Store at 20–25°C (68–77°F). Protect from light and moisture. Keep out of reach of children.
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