Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Sugamet 500mg is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. It is also used in combination with other oral hypoglycemic agents or insulin when diet and exercise alone do not provide adequate glycemic control.
Pharmacology:
Metformin, the active ingredient in Sugamet, is a biguanide class oral antihyperglycemic drug. It works by:
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Decreasing hepatic glucose production
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Decreasing intestinal absorption of glucose
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Improving insulin sensitivity by increasing peripheral glucose uptake and utilization
Unlike some other antidiabetic medications, Metformin does not cause hypoglycemia when used alone.
Dosage & Administration:
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Adults: The usual starting dose is 500 mg twice a day or 850 mg once a day, taken with meals. Dosage may be increased gradually, up to a maximum of 2000 mg per day, based on patient tolerance and glycemic control.
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Children: The usual starting dose is 500 mg twice a day, taken with meals. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg per day, given in divided doses.
Interaction:
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Co-administration with carbonic anhydrase inhibitors (e.g., topiramate, zonisamide) may increase the risk of lactic acidosis.
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Drugs that reduce Metformin clearance (e.g., cimetidine) may increase the accumulation of Metformin.
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Alcohol can potentiate the effect of Metformin on lactate metabolism, increasing the risk of lactic acidosis.
Contraindications:
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Severe renal impairment (eGFR below 30 mL/min/1.73 m²)
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Hypersensitivity to Metformin or any component of the formulation
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
Side Effects:
Common side effects include:
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Diarrhea
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Nausea
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Vomiting
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Flatulence
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Asthenia
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Indigestion
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Abdominal discomfort
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Headache
Pregnancy & Lactation:
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Pregnancy: Uncontrolled diabetes during pregnancy is associated with an increased risk of congenital abnormalities and perinatal mortality. Insulin is preferred for managing diabetes during pregnancy.
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Breastfeeding: Metformin is excreted into human breast milk. No adverse effects were observed in breastfed newborns/infants. However, a decision on whether to discontinue breastfeeding should be made, taking into account the benefit of breastfeeding and the potential risk to adverse effects on the child.
Therapeutic Class:
Biguanides
Storage Conditions:
Store below 30°C, protected from light and moisture. Keep out of reach of children.
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