PROVAL CR 500 MG

PROVAL CR 500 MG

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Product Code : 107719660900103

Short Description

PROVAL CR 500 mg is a controlled-release anticonvulsant medication used to treat various types of epilepsy, bipolar disorder, and to prevent migraines by stabilizing electrical activity in the brain.

Name	Brand	Generic Name	Strength	PPF	Price
PROVAL CR 500 MG	General Pharmaceuticals Ltd.	SODIUM LVALPORATE & VALPROIC ACIPROVAL CR	500 mg	TABLET	13

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Indications:
PROVAL CR 500 mg is indicated for:

Treatment of all types of epilepsy, including partial seizures, absence seizures (petit mal), generalized tonic-clonic seizures (grand mal), myoclonic seizures, atonic seizures, and mixed seizures with absence attacks.
Management of manic episodes associated with bipolar disorder.
Prophylaxis of migraine headaches.

Pharmacology:
Sodium Valproate, the active ingredient of this preparation, has anti-epileptic activity against a variety of seizures. The mechanism by which Sodium Valproate exerts its anti-epileptic effects has not been fully established. However, it is believed to increase brain levels of gamma-aminobutyric acid (GABA), which helps in controlling seizures.

Dosage & Administration:

Epilepsy:
- Adults: Initially, 600 mg daily in 2 divided doses, preferably after food. The dose may be increased by 200 mg/day at 3-day intervals to a maximum of 2.5 g daily in divided doses until control of seizures is achieved. The usual maintenance dose is 1–2 g daily (20–30 mg/kg daily).
- Children (over 20 kg): Initially 400 mg daily in divided doses, increased until control (usually in the range of 20–30 mg/kg daily); maximum 35 mg/kg daily.
- Children (up to 20 kg): Initially 20 mg/kg daily in divided doses.
Febrile Convulsions: 20–30 mg/kg/day in 3 divided doses.
Bipolar Disorder: Initially 600 mg daily (20–30 mg/kg/day) in 2–3 divided doses. The maintenance dosage is 1000–2000 mg daily.
Migraine Prophylaxis: 400–600 mg daily, although some may require 1000–1500 mg daily.

Administration:
Take orally with or without food, at the same time each day. Swallow tablets whole; do not chew or crush.

Interaction:
Sodium Valproate may interact with other anticonvulsants (e.g., phenobarbital, phenytoin), anticoagulants (e.g., warfarin), and certain antidepressants. Monitor for potential interactions and adjust dosages accordingly.

Contraindications:

Hypersensitivity to Sodium Valproate or any component of the formulation.
Severe liver dysfunction.
Urea cycle disorders.
Mitochondrial disorders.

Side Effects:

Common: Nausea, vomiting, dizziness, drowsiness, tremors, weight gain, hair loss.
Less Common: Abdominal pain, diarrhea, blurred vision, rash, increased appetite.
Serious: Hepatic dysfunction, pancreatitis, thrombocytopenia, hyperammonemia.

Pregnancy & Lactation:

Pregnancy: Contraindicated, especially during the first trimester, due to potential teratogenic effects.
Lactation: Not recommended; excreted in breast milk and may affect the nursing infant.

Therapeutic Class:
Anticonvulsants, Mood Stabilizers

Storage Conditions:
Store below 30°C in a dry place, protected from light. Keep out of reach of children.