Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
PROVAL CR 200 mg is indicated for:
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Treatment of epilepsy, including partial seizures, absence seizures, and generalized tonic-clonic seizures.
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Management of manic episodes associated with bipolar disorder.
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Prophylaxis of migraine headaches.
Pharmacology:
Sodium Valproate is an anticonvulsant that works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, inhibiting abnormal electrical activity and stabilizing neuronal membranes.
Dosage:
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Epilepsy: Initial dose of 10–15 mg/kg/day, increasing gradually to 60 mg/kg/day.
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Bipolar Disorder: Typically 750 mg/day, adjusted based on clinical response.
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Migraine Prophylaxis: 250 mg twice daily, adjusted as needed.
Administration:
Take orally with or without food, at the same time each day. Swallow tablets whole; do not chew or crush.
Interaction:
May interact with other anticonvulsants (e.g., phenytoin, carbamazepine), anticoagulants (e.g., warfarin), and certain antidepressants. Monitor for potential interactions and adjust dosages accordingly.
Contraindications:
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Hypersensitivity to Sodium Valproate or any component of the formulation.
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Severe liver dysfunction.
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Urea cycle disorders.
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Mitochondrial disorders.
Side Effects:
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Common: Nausea, vomiting, dizziness, drowsiness, tremors, weight gain, hair loss.
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Less Common: Abdominal pain, diarrhea, blurred vision, rash, increased appetite.
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Serious: Hepatic dysfunction, pancreatitis, thrombocytopenia, hyperammonemia.
Pregnancy & Lactation:
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Pregnancy: Contraindicated, especially during the first trimester, due to potential teratogenic effects.
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Lactation: Not recommended; excreted in breast milk and may affect the nursing infant.
Therapeutic Class:
Anticonvulsants, Mood Stabilizers
Storage Conditions:
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
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