RANOLA ER 500 MG

RANOLA ER 500 MG

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Product Code : 107719656300201

Short Description

Ranola ER 500 mg is an extended-release tablet containing Ranolazine, used to treat chronic angina by improving blood flow to the heart muscle.

Name	Brand	Generic Name	Strength	PPF	Price
RANOLA ER 500 MG	General Pharmaceuticals Ltd.	RANOLAZINE	500 mg	TABLET	16.05

৳ 16.05

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Indications:
Ranola ER 500 mg is indicated for:

Chronic Angina:
- Treatment of chronic angina in patients with coronary artery disease.
- Can be used alongside other anti-anginal medications like beta-blockers, nitrates, and calcium channel blockers.
- Particularly beneficial for patients on high doses of amlodipine who still experience angina episodes.

Pharmacology:
Ranolazine, the active ingredient in Ranola ER 500 mg, exerts its anti-anginal and anti-ischemic effects through mechanisms that do not primarily involve reductions in heart rate or blood pressure. The exact mechanism of action is not fully understood, but it is believed to involve inhibition of the cardiac late sodium current (I_Na), which may reduce intracellular calcium overload and improve myocardial function. Additionally, Ranolazine prolongs the QT interval due to inhibition of the rapid delayed rectifier potassium current (I_Kr), which extends the ventricular action potential.

Dosage & Administration:

Initial Dose:
- 500 mg orally twice daily.
Maintenance Dose:
- May be increased to 1000 mg orally twice daily based on clinical response.
Administration:
- Take with or without food.
- Swallow tablets whole; do not crush, break, or chew.
- Maximum recommended daily dose: 2000 mg (1000 mg twice daily).

Side Effects:
Common side effects may include:

Cardiac:
- Bradycardia, palpitations.
Gastrointestinal:
- Nausea, constipation, abdominal pain.
Central Nervous System:
- Dizziness, headache, blurred vision.
General:
- Peripheral edema, fatigue.

Precautions & Warnings:

QT Prolongation:
- Monitor ECG periodically, especially in patients with risk factors for QT prolongation.
Drug Interactions:
- Use caution when co-administering with other drugs that affect the QT interval or are metabolized by CYP3A and CYP2D6 enzymes.
Renal Impairment:
- Use with caution in patients with renal impairment; dose adjustment may be necessary.

Pregnancy & Lactation:

Pregnancy Category:
- Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation:
- It is not known whether Ranolazine is excreted in human milk. Caution should be exercised when administering to breastfeeding women.

Storage Conditions: