ROSUGEN 10 MG

ROSUGEN 10 MG

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Product Code : 107719657801301

Short Description

Rosugen 10 mg Tablet is a statin medication used to lower "bad" cholesterol (LDL) and triglycerides, and raise "good" cholesterol (HDL), thereby reducing the risk of heart attack and stroke.

Name	Brand	Generic Name	Strength	PPF	Price
ROSUGEN 10 MG	General Pharmaceuticals Ltd.	ROSUVASTATIN	10 mg	TABLET	27

৳ 27

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Rosugen 10 mg Tablet is indicated for the treatment of:

Heterozygous familial and non-familial hypercholesterolemia
Homozygous familial hypercholesterolemia
Mixed dyslipidemia (Fredrickson Type IIa and IIb)
Primary prevention of cardiovascular disease

Pharmacology:
Rosugen 10 mg Tablet contains Rosuvastatin, a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. It produces its lipid-modifying effects in two ways:

Increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL.
Inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage:

Adults:
- Starting dose: 5–10 mg once daily.
- Maintenance dose: 5–40 mg once daily.
- Maximum dose: 40 mg daily for patients not reaching LDL-C goal with 20 mg.
Pediatric patients with HeFH (8 to less than 10 years):
- 5–10 mg/day.
Pediatric patients with HeFH (10 to 17 years):
- 5–20 mg/day.
Pediatric patients with HoFH (7 to 17 years):
- 20 mg/day.

Administration:
Rosugen 10 mg Tablet can be taken with or without food, at any time of day. Swallow the tablet whole; do not chew, crush, or break it.

Interaction:

Cyclosporine: Combining these medications increases Rosugen exposure. The recommended dose should not exceed 5 mg once daily.
Gemfibrosil: It is advisable to avoid combining these drugs. If necessary, limit the dosage to 10 mg once daily when used together.
Lopinavir/Ritonavir or Atazanavir/Ritonavir: When used in combination, these medications can elevate Rosugen exposure. The recommended dose should be limited to 10 mg once daily.
Coumarin anticoagulants: Combining with coumarin anticoagulants can prolong the international normalized ratio (INR). Achieve a stable INR before initiating treatment and monitor it frequently until it remains stable during therapy.
Concomitant lipid-lowering therapies: When used with fibrates and niacin products, there may be an increased risk of skeletal muscle effects.

Contraindications:
Rosugen 10 mg Tablet is contraindicated in patients with:

Known hypersensitivity to Rosuvastatin or any component of the formulation.
Active liver disease or unexplained persistent elevations in hepatic transaminase levels.
Pregnancy and breastfeeding.

Side Effects:
Common side effects include:

Muscle pain (myalgia)
Weakness
Headache
Abdominal pain
Dizziness
Joint pain
Nausea

Pregnancy & Lactation:

Pregnancy: Rosugen 10 mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding: Rosugen 10 mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Therapeutic Class:
Other Anti-anginal & Anti-ischemic drugs, Statins

Storage Conditions:
Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.