akloc 5 mg Tablet is a medication manufactured by Popular Pharmaceuticals Ltd. in Bangladesh. Its active ingredient is Tofacitinib, a Janus kinase (JAK) inhibitor. Tofacitinib works by modulating the JAK-STAT signaling pathway, which is involved in the body's immune response. By inhibiting this pathway, Jakloc helps reduce inflammation and is used to treat conditions like rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in adults who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs)