Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
ZEMICEF 50 ML is indicated for the treatment of the following infections caused by susceptible microorganisms:
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Upper Respiratory Tract Infections (URTI):
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Otitis media
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Pharyngitis and tonsillitis caused by Streptococcus pyogenes
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Lower Respiratory Tract Infections:
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Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae
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Urinary Tract Infections:
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Cystitis, cystourethritis, pyelonephritis caused by Escherichia coli and Proteus mirabilis
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Sexually Transmitted Diseases:
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Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae
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Other Infections:
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Typhoid fever caused by Salmonella typhi
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Pharmacology:
Cefixime is a third-generation semisynthetic cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. It exhibits bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Cefixime is highly stable in the presence of beta-lactamase enzymes, making it effective against organisms resistant to penicillins and some cephalosporins. Absorption is approximately 40% to 50%, irrespective of food intake.
Dosage & Administration:
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Adults and Children over 12 years:
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200–400 mg daily, administered as a single dose or in two divided doses.
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For uncomplicated gonorrhea: 400 mg as a single dose.
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For typhoid fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, extendable up to 14 days based on infection severity.
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Children (6 months and older):
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8 mg/kg/day, administered as a single dose or in two divided doses.
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Specific dosing based on age:
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6 months to 1 year: 75 mg daily
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1 to 4 years: 100 mg daily
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5 to 10 years: 200 mg daily
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11 to 12 years: 300 mg daily
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For typhoid fever: 15–20 mg/kg/day, divided into two doses, for 7–14 days.
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Administration:
Take ZEMICEF 50 ML orally with or without food. Shake the bottle well before each use. Use the provided measuring device to administer the prescribed dose. Do not exceed the recommended dose.
Interaction:
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Carbamazepine: Concurrent use may increase plasma concentrations of carbamazepine.
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Warfarin and other anticoagulants: Concurrent use may prolong prothrombin time. Monitoring is recommended.
Contraindications:
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Hypersensitivity to Cefixime or other cephalosporin antibiotics.
Side Effects:
Common side effects include:
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Gastrointestinal disturbances:
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Diarrhea
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Nausea
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Abdominal pain
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Dyspepsia
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Vomiting
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Flatulence
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Central nervous system effects:
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Headache
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Dizziness
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Hypersensitivity reactions:
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Rash
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Pruritus
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Urticaria
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Drug fever
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Arthralgia
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These reactions are generally mild and resolve upon discontinuation of therapy.
Pregnancy & Lactation:
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Pregnancy: Use during pregnancy should be considered only if the potential benefit justifies the potential risk to the fetus.
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Lactation: Cefixime is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Therapeutic Class:
Third-generation cephalosporin antibiotic.
Storage Conditions:
Store below 30°C in a cool, dry place, away from light. Keep out of reach of children.
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