Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
VONOMAX 20 MG is indicated for:
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Gastric ulcer
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Duodenal ulcer
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Reflux esophagitis
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Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration
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Prevention of recurrence of gastric or duodenal ulcer during NSAID administration
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Adjunct to Helicobacter pylori eradication in the following conditions:
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Gastric ulcer
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Duodenal ulcer
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Gastric mucosa-associated lymphatic tissue (MALT) lymphoma
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Idiopathic thrombocytopenic purpura
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Post-endoscopic resection of early-stage gastric cancer
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Helicobacter pylori gastritis
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Pharmacology:
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits H⁺, K⁺-ATPase in a reversible and potassium-competitive manner. It does not require activation by acid and has a strong basicity, allowing it to reside on the acid production site of gastric parietal cells for an extended period, thereby inhibiting gastric acid production effectively.
Dosage & Administration:
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Gastric and Duodenal Ulcer: 20 mg once daily for 6–8 weeks.
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Reflux Esophagitis: 20 mg once daily for 4–8 weeks. If necessary, the dose may be increased to 20 mg once daily.
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Maintenance Therapy for Reflux Esophagitis: 10 mg once daily. If efficacy is inadequate, the dose may be increased to 20 mg once daily.
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Prevention of Recurrence of Ulcers During Low-Dose Aspirin or NSAID Administration: 10 mg once daily.
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Helicobacter pylori Eradication (Triple Therapy): 20 mg twice daily for 7 days, in combination with 750 mg amoxicillin and 200 mg clarithromycin.
Administration:
Take VONOMAX 20 MG orally with or without food, as directed by your healthcare provider. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
Interaction:
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Contraindicated Drugs: Atazanavir, nelfinavir, and rilpivirine due to potential interactions.
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Caution: Use with caution in patients receiving drugs that prolong the QT interval or are metabolized by certain liver enzymes.
Contraindications:
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Hypersensitivity to Vonoprazan or any excipient of the product.
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Concomitant use with atazanavir, nelfinavir, or rilpivirine.
Side Effects:
Common side effects may include:
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Diarrhea
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Constipation
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Drug eruption
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Urticaria
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Hepatotoxicity
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Jaundice
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Rash
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Nausea
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Abdominal distension
Serious side effects may include:
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Anaphylactic shock
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Liver function test abnormalities (e.g., increased ALT, AST, ALP)
Pregnancy & Lactation:
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Pregnancy: Use only if the expected therapeutic benefit justifies the potential risk to the fetus.
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Lactation: It is advisable to avoid the administration of Vonoprazan to nursing mothers. However, when the administration is indispensable, nursing should be discontinued.
Therapeutic Class:
Potassium-competitive acid blocker (P-CAB)
Storage Conditions:
Store below 30°C in a cool and dry place, away from light. Keep all medicines out of the reach of children.
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