Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
SULFAZIN 500 MG is indicated for the treatment of ulcerative colitis, a chronic inflammatory bowel disease, and rheumatoid arthritis, an autoimmune disorder that causes joint inflammation. It helps reduce pain, swelling, and inflammation in both the intestines and joints.
Pharmacology:
SULFAZIN 500 MG contains sulfasalazine, a combination of sulfapyridine and 5-aminosalicylic acid (5-ASA). In the colon, it is broken down by bacteria to release these two active components. 5-ASA acts locally to reduce inflammation in the intestinal lining, while sulfapyridine is believed to help modulate immune responses, making the drug effective in treating autoimmune conditions like rheumatoid arthritis.
Dosage:
-
Ulcerative Colitis (Adults): Initially 1–2 g/day in divided doses, gradually increased to 2–4 g/day as needed.
-
Rheumatoid Arthritis: Typically starts with 500 mg/day, increased to 2–3 g/day in divided doses.
-
Children: Dosage is adjusted based on weight and condition, under medical supervision.
-
Take with meals to minimize gastrointestinal side effects.
Administration:
-
Oral administration only.
-
Take with food and a full glass of water.
-
Do not crush or chew the tablets unless advised.
-
Drink plenty of fluids during treatment to avoid kidney stones.
Interaction:
-
May enhance the effects of anticoagulants, sulfonylureas, and methotrexate.
-
Reduces the absorption of digoxin and folic acid.
-
Use with caution with nephrotoxic drugs and other immunosuppressants.
-
May reduce fertility in males (reversible after discontinuation).
Contraindications:
-
Hypersensitivity to sulfonamides, salicylates, or any component of the product.
-
Severe liver or kidney impairment.
-
Porphyria.
-
Intestinal or urinary obstruction.
Side Effects:
-
Common: Nausea, headache, rash, loss of appetite, stomach upset.
-
Serious: Blood disorders (anemia, leukopenia), liver toxicity, kidney problems, severe skin reactions.
-
Regular monitoring of blood counts and liver/kidney function is recommended during long-term therapy.
Pregnancy & Lactation:
-
Pregnancy: Category C. Should only be used if clearly needed and prescribed by a doctor. May interfere with folate metabolism.
-
Lactation: Excreted in breast milk. May cause diarrhea or blood disorders in infants—use only under medical supervision.
Therapeutic Class:
-
Anti-inflammatory agents for inflammatory bowel disease (IBD)
-
Disease-modifying antirheumatic drugs (DMARDs)
Storage Conditions:
-
Store below 25°C in a dry place, away from light.
-
Keep out of reach of children.
-
Do not use after the expiry date printed on the pack.
.jpg)
Change Language