Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Pantogut 20 mg is indicated for:
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Peptic ulcer diseases
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Gastroesophageal reflux disease (GERD)
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Ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs)
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Eradication of Helicobacter pylori (in combination with antibiotics)
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Zollinger-Ellison Syndrome
Pharmacology:
Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.
Dosage & Administration:
Oral:
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Benign gastric ulcer: 40 mg daily in the morning for 4 weeks; continued for further 4 weeks if not fully healed.
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Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks; continued for further 4 weeks if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
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Duodenal ulcer: 40 mg daily in the morning for 2 weeks; continued for further 2 weeks if not fully healed.
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Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxicillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week.
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Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those requiring long-term NSAID treatment.
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Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses.
IV Injection:
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Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
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Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
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Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
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Prophylaxis of acid aspiration: 80 mg IV every 12 hours for 24 hours, followed by 40 mg every 12 hours
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Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.
Interaction:
No significant drug interactions have been observed in clinical studies.
Contraindications:
Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.
Side Effects:
Pantogut is well tolerated in both short-term and long-term treatment. Common side effects include headache and diarrhea. Rare side effects may include abdominal pain, flatulence, rash, insomnia, and hyperglycemia.
Pregnancy & Lactation:
Pantoprazole is classified as Pregnancy Category B by the US FDA. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.
Precautions & Warnings:
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Pantogut tablets should not be split, chewed, or crushed.
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Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis-related disorders.
Therapeutic Class:
Proton Pump Inhibitor
Storage Conditions:
Store in a cool, dry place away from light. Keep out of reach of children.
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